Wellcome Sanger Institute, Newcastle University and Cambridge University (UK) this week publish the most comprehensive mobile card in the cover of Nature magazine, including the contact area between the mother and her future child. This atlas of the cellular composition demonstrates the potential keys to prevent the most common early problems and achieve successful pregnancy without complications.
Researchers, including their Spanish brothers Roser and Michel Vento-Tormo, have managed to map the 70,000 transcriptominal (transcriptional DNA) of healthy cells aged 6 to 14 due to complex bioinformatics and genomic methods.
"This idea was to understand the mechanisms that arise without complications in the first trimester of pregnancy. Thus, a reference card for all the cells and their interaction has been developed to compare the difference between healthy pregnancy and the future, Roser Vento-Tormo, of the Weller Sanger Institute Institute, explains.
"We have determined that genes change immune system and allow the fetus to develop properly" Roser Vento explains
The analysis is focused on the first trimester as it is the decisive moment in determining the survival of the embryo (and subsequent fetus). In these early weeks, placenta has a sperm cell that interacts with the body's body to change the immune response that tries to avoid the condition of failure.
Thanks to them, the embryo maintains the deoxygenated uterus, which is the inner layer of the pregnant uterus, which starts using implantation. In addition, it will serve as a means of feeding and oxygenation in the next few months.
"For the first time in history, we have noticed what genes are active in the decidua and placenta cells, so we can identify things that change the mother's immune system and allow the fetus to develop properly," says Vento.
There are few complications
The chances of pregnancy complications are high in the first weeks when the fetus is not grouped yet. In fact, two of the three three cases occur spontaneously during the first trimester.
Vento explains that research has yet to be made to understand that pregnancy is right. However, "in the future we can predict that any changes to the analysis of patient samples at the beginning of pregnancy".
Researcher at Newcastle University, Muzifah Hansfaffe, adds that these results "have a major impact on the pregnant woman's understanding of what happens when she experiences preeclampsia or even abortions."
In the future, experts can predict any change in the beginning of pregnancy
Experts believe that this indicator also has a significant impact on cancer research, as it is known that cancer cells use similar mechanisms to avoid the immune system and increase blood flow and weight.
Public access database
The results were achieved thanks to the creation of a Miquel Vento-Tormo and its team developed jointly with the YDEVS Spanish Software Development Company.
CellPhoneDB propagates information about molecules and their interactions, and predicts the most likely cellular interactions. According to Roser Vento, "this tool can be used for any fabric. Together with Virgo Mikel we made it accessible to all.
Mobile card of the human body
This study is part of the Human Trapezoidal Initiative, one of the key supervisors of the publication, and an international human consortium led by Wellcome Sanger Institute researcher Sara Teihman.
"With this initiative, we plan to create a complete reference card for all human cells," concluded Vento.