Friday , March 5 2021

Can not sleep at night? The artificial light emitted from the phone is confusing to our internal clocks

WASHINGTON D.C. [USA]: So far, we all know that we spend too much time watching the screens – whether computers, phones, iPads – play a lot on sleep. But do you know why?

The researchers pointed out that certain cells in the eyes treat the ambient light and reset our internal tactics, daily cycles of physiological processes known as the circadian rhythm. When these cells are exposed to artificial light late into the night, our internal timers can be confusing, which leads to a variety of health problems.

The study, which Salk Institute researchers published in the Cell Reports magazine.

The results can lead to a new treatment for migraines, insomnia, milk constipation and circadian rhythm disorders, which are related to cognitive dysfunction, cancer, obesity, insulin resistance, metabolic syndrome and more.

"We are continuously exposed to artificial light, whether it's time of the screen, to spend an indoor day, or to be awake at night," said Professor Salk Satchin Panda, senior author of the study. "This way of life causes disorders in our circadian rhythms and has harmful effects on health."

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The recesses of our eyes contain a sensory membrane called retina, whose lowest layer contains a small sub-population of light-sensitive cells that function as pixels in a digital camera. When these cells are exposed to the current light, a protein called melanopsin is continuously regenerated inside them, signaling the levels of ambient light directly into the brain to regulate awareness, sleep and alertness. Melanopsin plays a key role in synchronizing our internal clock after 10 minutes of illumination and, under strong light, suppresses the melatonin hormone responsible for regulating sleep.

"Compared to other cells in the eyes of the eyes, melanopsin cells react as long as the light goes on, and even a few seconds," said Ludovic Mure, the first author of the newspaper. "It's critical, because our circadian clocks are designed to respond only to extended lighting."

In the new work, Salk researchers used molecular tools to include the production of melanopsin in retinal cells cells in mice. They found that some of these cells have the ability to maintain light reactions when exposed to repeated long light pulses, while others become desensitized.


Conventional wisdom has found that proteins that are called stops, which stop the activity of certain receptors, should stop the sensitivity of the cells within a few seconds from which the lights appear. The researchers were surprised when they discovered that the arrested factors were necessary for melanopsin to continue to respond to prolonged illumination.

In mice who did not have any version of protein arrestin (beta arrestin 1 and beta arrestin 2), melanopsin retinal melting cells did not manage to provide sensitivity to light under long-term illumination. The reason, as it turns out, is that it arrests melanopsin regeneration in retinal cells.

"Our study suggests that two arrests in a special way achieve regeneration of melanopsin," said Panda. "One arrests its conventional job of arresting the response, and the other helps the melanopsin protein to liberate its retinal light factor. When these two steps are done in a fast sequence, the cell seems to continuously react to light."

A better understanding of melanopsin interactions in the body and how they react to light, Panda hopes to find new targets to counter the distorted circadian rhythms because of, for example, artificial lighting. Earlier research team Pande discovered that chemicals called opsinamides could block the activity of melanopsin in mice without affecting their vision, providing a potential therapeutic avenue to address the hypersensitivity to light experienced by vulnerable migraine sufferers.

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July 28, 2018

Low Immunity and Energy Saving Considering Your Health Damage?

We often strive to become less active due to changes in time. After an uncomfortable arrangement, we are often deprived of "me-time", which is why we resort to unhealthy eating.

Good nutrition, lots of water and an active lifestyle are some of the habits you need to adopt this season, along with the following tips:

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