Tuesday , August 3 2021

Cellular modeling of neurons with SMMA engine can be useful research tool



The 3-D cell model of stem cells can imitate motor neurons spinal cord cloud (SMA) a new physiological tool for the study of patients and diseases and screen therapy candidates.

Research, »Cellulose-cyclone inhibitors protect motor neurons in an organoid-like pattern of spinal cord atrophy,"Published Cell death and illness.

In most cases SMA is associated with genetic mutations SMN1 the gene that leads to a sharp decrease in the level of life of the poisonous neuron (SMN) protein.

It is important to understand why this protein is one of the most severe cell types, although motor proteins are made with many tissues.

Although the animal-based study and the commencement of the QMA may occur in the early months of life, researchers suggest that the motor neurons in the CMA did not form properly and ultimately survived the neurodegulatory disorder, following a subsequent collapse. But this hypothesis remains controversial.

Under the supervision of the researchers National University of Singapore, the team created these laboratory cellular models, which allowed them to explore the development and neurodegeneration of the moving neurons from the SMA.

The so-called neuronic organelles model is a three-dimensional model of the "in the wave" motor neurons in the spinal cord taken from the human induced pluripotentiary stem cells (iPSCs). These cells skin or blood cells that are re-inserted into the stem cell, allowing them to develop an unlimited source of any type of cell required.

Neuronal organisms are three-dimensional culture systems that give a new shape to the development and organization of the central nervous system. "There is a huge potential for the study of human neurons," researchers say.

Scientists have been able to extract vertebrate organs from healthy cells and donate cells from the SMA. These organoids contain many vertebral spinal cord neurons, astrocytes, and interiors – this is a natural in vivo spinal nerve center.

Using these organoids, scientists compared QMA with the development of motor neurons from healthy subjects. Researchers have not found any changes in the appearance of neuron precursor cells or mature neurons in the QMA.

The neuron of the SMA motor has died at speeds when the patient's donor (type 1 and type 2) has increased the severity of ZMA, the severity of motor neuron loss in the pelvic organs.

Researchers have closely studied the process of neuron cell death, and deactivated cellular replication of motor neurons from SMA patients. If replication was blocked by treating spinal cord organs with a small molecule inhibitor of the so-called pancreatic inhibitor, the SMA motorway survived significantly longer.

"It confirms that neuron organoids are responsible for small molecular screening techniques and can be considered as an additional screening step prior to copying in vivo models. "

These 3-D models can effectively multiply the spectrum of the SMA spectrum and be used to investigate how neurodegeneration is performed.


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