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Scientists are able to reprogram cells to control the infections of THE UNIVERSAL



Scientists from the Pasteur Institute in France managed to reprogram HIV control stations such as HIV, published in the journal Nature Metabolism.

Some people have the ability to naturally control HIV without treatment, although one percent of patients can not detect blood multiplication after more than 10 years of infection without treatment.

In 2007, Pasteur Institute scientists described the extraordinary antiviral activity of CD8 lymphocytes in these patients, who are capable of rapidly destroying infected CD4 cells.

Scientists continued with their research to identify the specific characteristics of these cells, so that they can give the same characteristics to non-controllable cells of the cells.

In this way, scientists have discovered that CD8 anti-HIV cells in controllers not only have enormous antiviral potential, but are also programmed to survive, while in uncontrolled cells the cell predisposes them to exhaustion and death cellular

The CD8 cells of the controller use various metabolic resources, which are based on the energy supplied by their mitochondria, which enables cells to survive under stressful conditions. In contrast, non-controlling cells depend on one energy source (glucose) and have limited mitochondrial activity.

In the laboratory, scientists have been able to stimulate mitochondrial activity in anti-HIV non-control cells. To do this, they used the substance that the light immune system known as interleukin 15 (IL-15) to stimulate the activity of mitochondrial non-control cells and increase their anti-HIV potential.

"Our research shows that even if the anti-HIV CD8 cells of the controller are relatively inefficient in relation to those controllers, the differences can be overcome," experts say.


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