Monday , May 10 2021

Needs the brain: helping the brain to cope with the breath Science



Wednesday morning is rainy and Dr. Andrew Adell is walking closer to Australia than the Neuroscience Research in Randwick, as usual.

It's not just polite, no-wave, but it's a precautionary measure; several times in the protective container layers and in an ice-covered machine, the human brain was alive several hours ago.

It is not a usual brain – any brain can be said to be simple, but hidden inside a dead secret. Until recently, a man standing in a pink, gray, and white cloth dying of one of the neurodegenerative diseases that caused the death of our aging. Perhaps, Alzheimer's disease, which slowly shakes the body and the mindset of the primordial dementia or Parkinson's disease, which have gradually changed their personality or their identity.

Andrew Affleck.



Whatever their life, this body will go to the Bank of Sydney.

***

Affleck says: "I am convinced that this path will bring us to the brain. At the Sydney Brain Bank, located in NeuRA, scientists hope to gather new and important ideas from their fabric. Perhaps one day this concept leads to a better understanding, good treatment, and even treatment.

"As Affleck, a banker at the Sydney Central Bank, says every charity that brings the fabric to the laboratory says to me that it is really comforting.

"It's really fun, you want to do whatever you can; not only in science, but also in families.

Adele Lousson, a research assistant, prepares for dyeing sections of paraffin fabric. Brain Bank is located in Randwick, NSW, Australia.



The Sydney Bank has a typical research facility: mattress offices, glass windows, laboratories, equipment, glass containers and filling labs, but all are thoroughly clean and clean. Here, more than 600 brain-pelvic threads, which scientists have been able to do, have no luxury in luxury jars or Hollywood-escules.

Under the glowing labs, several layers are typically the size of a typical desk room in the basement, which is accessible through a hoist. It is filled with shelves of the cells, which are highlighted by pressing the button.

Shelves are covered with white plastic shells, each containing half of the formalin stored in the formulas. Director of Sydney Bank, Dr. Claire Shepherd apologizes.

Dr. Clever Shepherd.



"The bucket looks very interesting or non-scientific, but in the years of experience, they have said that they are the best way to keep the brain clean," he explains.

The room is controlled by comfortable heating of the room and the power racks move one another and keep silent, apart from several electronic signals. This is a peaceful space; like being in a room full of deep roofs.

The second half of this stored brain is maintained at an ultra-low freezer level of up to -80 degrees.

The Sydney Brain Bank is one of many forms of Australia and the world that aims to gather bone and spinal bone from people who have been exposed to various diseases and conditions. This tissue is looking for researchers to find out why these diseases are taking place and what to do to cure, stop, or prevent them.

The main purpose of the Sydney Bank Maine is neurogenic diseases; Parenxone's disease, motor neuron disease, Huntington's disease, and progressive supracellular shunting.

The brain's charity is another animal for the charity of the body, at least for transplantation and the other for research.

"Many people think they are a charity card and ask me," Can I give my brain a favor because I'm a body donor? "Shepherd asks. But giving to the brain is much more complicated because scientists need to know about the donor's life to get the most out of this charity.

Donors who have joined the Sydney Money Bank are recruited through a network of specialized neurologists and clinics around Sydney, where they collect standardized patient data, such as medical history and unique histories and disease specificities. These data include regular imaging of blood as well as MRI technology.

"The value of the fabric has really been enriched because we have all the information about not only the fabric, but also the person who is in the life, and this is standardized information about individuals," says Shepherd.

Andrew Affleck, removal of fabric parts from automated slide coloring.



However, personal identification and life of donors are hidden from workers and researchers working on fabric. This should not only be for confidentiality, but also for the benefit of the employees of the charitable brain.

Sheand reminded the family members of the deceased donor, who sent the Bank a home book about the donor's life and who they were. When he saw this picture of donated life, he was impressed by the Shopan and this emotion is still very close to his face.

"I am the guardian of the brain," he says. "It does not mean I do not know who I am, but I do not have a close relationship with him, if it were to affect that level every day, it would be dangerous."

***

Time is the enemy of the charity. If a chronic organ like the body, heart, kidney, or brain does not give oxygen to the organism, the tissue is broken down and the quality of the information becomes worse.

Andrew Affleck, removal of fabric parts from automated slide coloring.



Laboratory bags in the laboratory.



Employees of the Sydney Money Bank will hold pagers 24 hours a day, seven days a week, 365 days a year. When the donor dies, one of the first calls from family, guardians or healthcare professionals is for that pager.

What to do is quick. Whoever calls, then connects with the body that takes away the body and the funeral service.

"The main purpose of our family is not to stop the funeral procession but to have the best opportunities, and we will strive to keep them up to date," Affleck explained.

The removal of the brain and spinal cord occurs at one of the other operating moratoria in Sydney, if it is financed. This relatively fast process, for at least two hours, then any affliction or caller tissue returns to the Bank of Maine.

After the arrival, the brain is divided into two halves. One half of the frozen, samples of fabrics that are distributed from the brain are of particular interest to researchers. The frozen fabric may be further studied under a microscope, but even more important, freezes the biochemistry of DNA, protein, and tissue.

Adele Lousson, a research assistant, prepares for dyeing sections of paraffin fabric.



The second half of the brain is dipped into the formalin for two weeks, allowing the liquid conservator to enter the brain completely. At the end of this process, this hemisphere is kept at a distance of 3mm on thin sheets of acetate, white bucket in tents, in the basement shelves. At this point, Brain Bank employees receive small samples or "blocks" that are interested in further research on different parts of the brain.

"Maybe there are mild or tinted colors, or is there something else to do under the microscope?" Affleck says. These small pieces are also processed with various stains that show the presence or absence of different proteins and structures.

The last step is a complete, standardized report that can be traced back to Brain Bank about what it has heard about donors' life and disease. This information is a starting point for researchers interested in tissue research. Probably these are folders, slide boxes, fabric samples and data pages that they are looking for.

***

What about donors and their families? What do they do when they mark this box and give their consent to the most personal body that can be eliminated after their death?

Lucille Bloch has never heard about the kindness of the brain before joining the NeuRA research team leader, Professor John Hughes.

Lucille Bloch transfers the brain to the Bank of Sydney. Her dead husband, Keith Blok, also gave her brain.



A black and white photo of Lucille and Keith Blok.



Death mit Keith Blok also gave her brain.



He says: "The number of demmenia increases, and we need to think about treatment of hemorrhoids, and we need those who have the breathing, and we need brain after death."

Lucille's husband, Keita, diagnosed her frontomorphal dementia. After the lecture, she sat down with her and told her that they had learned.

She said, "Dear, now we have four children, and two grandchildren, I give my brain because I want to help if our children are with him and other people [get it]. «

Keith died 10 years ago, but Lucille sometimes goes to NeuRA. "I will join her," she says. The experience has turned him into a lawyer to learn and understand more about the charity work of the brain as well as the dementia. When the time comes, he also gives a brain.

Liza Webb's husband, Bob, two years ago, died of what he later diagnosed as progressive aphasia – gradual loss of language skills. However, this was a symptom of Parkinson's disease, which was not diagnosed until death.

Soon after Bob's diagnosis, the brain's sympathy came when NeuRA went for the test.

"His brain was only a part of the body; she was always glad to donate the organs, and the brain was only one organ, "says Lisa. "I think I have the same approach; I thought that if we could not do anything to help other people, I would be doing the same.

Bob's fabric is located in Sydney's brain, and it's the idea of ​​helping researchers find a sense of comfort.

"There are some things that I am going to do, in fact it does not really exist; he still does good, and that's a good thing.


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